Homeostatic control through the regulation of commensal bacteria by specific neurons

Researcher name

Project Summary

“The mind controls the body”. As expressed in this proverb, the close connection between the nervous system and the immune system has been inferred. The relationship between immune responses and nervous system has, however, remained unexplored since Metalnikov’s initial experiments in 1924.The PA identified neurons controlling intestinal flora, which is essential for host homeostasis. In this study, the three research groups of this university are fused to reveal the control mechanisms of the homeostasis by the neurons. The study will creates new research areas in control of immunity by nervous system.










1.  Decreased resistance to infection by neural suppression in the 49171 strain


To determine the structure of the neural circuit responsible for immune regulation, we screened the JaneliaGAL4 lines created by the “FlyLight” project, and identified a line (49171 line) out of 291 lines in which neural inhibition reduced resistance to Gram-negative and Gram-positive bacterial infections.



2. Clustering analysis of genes under control of NP3253 neurons


To elucidate how NP3253 neurons regulate intestinal immunity and maintain homeostasis, we performed a comprehensive analysis of gene expression in the intestinal tract dependent on NP3253 neurons. 1139 genes were identified, supporting, in terms of gene expression, that NP3253 neurons regulate gut microbiota.